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Yu H., G. L. Chadwick, U. F. Lingappa, and J. R. Leadbetter (2022). Comparative genomics on cultivated and uncultivated, freshwater and marine Candidatus Manganitrophaceae species implies their worldwide reach in manganese chemolithoautotrophy. Mbio 13(2):e0342121

Ne Ville, C. J., J. R. Leadbetter, P. M. Orwin (2021). Hybrid Assembly of the quorum-quenching isolate Variovorax paradoxus VAI-C Genome Sequence. Microbiol. Resour. Announc. 10 (19), e00265-21.

Mickol, R. L., A. S. Louyakis, H. L. Kee, L. K. Johnson, S. C. Dawson, K. R. Hargreaves, G. L. Chadwick, D. K. Newman, J. R. Leadbetter, and C. T. Brown (2021). Draft genome sequence of the free-living, iridescent bacterium Tenacibaculum mesophilum strain ECR.  Microbiol. Resour. Announc. 10 (1), e01302-20.

Tsypin, L. M., S. H. Saunders, Y. Bar-On, J. R. Leadbetter, and D. K. Newman (2020). Draft genome sequence of the redox-active enteric bacterium Citrobacter portucalensis strain MBL. Microbiol. Resour. Announc. 9 (32), e00695-20.


Yu, H., and J. R. Leadbetter (2020). Bacterial chemolithoautotrophy via manganese oxidation. Nature 583:453–458. (Cover Article).

    Publicly Accessible (Readable) Reprint:

Kee, H. L., I. V. Mikheyeva, R. L. Mickol, S. C. Dawson, D. K. Newman, and J. R. Leadbetter (2019). Draft genome sequence of the iridescent marine bacterium Tenacibaculum discolor Strain IMLK18. Microbiol. Resour. Announc. 8(5):e01683-18.

Choi, H. M., Calvert, C. R., Husain, N., Huss, D., Barsi, J. C., Deverman, B. E., Hunter, R. C., Kato, M., Lee, S. M., Abelin, A. C., Rosenthal, A. Z., Akbari, O. S., Li, Y., Hay, B. A., Sternberg, P. W., Patterson, P. H., Davidson, E. H., Mazmanian, S. K., Prober, D. A., van de Rijn, M., J. R. Leadbetter, D. K. Newman, C. Readhead, M. E. Bronner, B. Wold, R. Lansford, T. Sauka-Spengler, S. E. Fraser, and N. A. Pierce (2016). Mapping a multiplexed zoo of mRNA expression. Development 143:3632–3637.

Mariita, R. M., S. Bhatnagar, K. Hanselmann, M. J. Hossain, J. Korlach, M. Boitano, R. J. Roberts, M. R. Liles, A. G. Moss, J. R. Leadbetter, D. K. Newman, and S. C. Dawson (2015). Complete genome sequence of Streptomyces sp. strain CCM_MD2014, isolated from topsoil in Woods Hole, Massachusetts. Genome Announc. 3(6), e01506-15.

Mariita, R. M., S. Bhatnagar,  K. Hanselmann, M. J. Hossain, J. Korlach, M. Boitano, R. J. Roberts, M. R. Liles, A. G. Moss, J. R.  Leadbetter, D. K. Newman, and S. C. Dawson (2015). Complete genomes sequence of Curtobacterium sp. strain MR_MD2014, isolated from topsoil in Woods Hole, Massachusetts. Genome Announc. 3(6), e01504-15.

Tocheva E. I.,  E. G. Matson, S. N. Cheng, W. G. Chen, J. R. Leadbetter, G. J. Jensen (2014). Structure and expression of propanediol utilization microcompartments in Acetonema longum. J. Bacteriol. 196:1651‐58.


Lucey, K. S. and J. R. Leadbetter (2014). Catechol 2,3-dioxygenase and other meta-cleavage catabolic pathway genes in the "anaerobic" termite gut spirochete Treponema primitia. Mol. Ecol. 23:1531‐43.

Han, J.-I., J. C. Spain, J. R. Leadbetter, G. Ovchinnikova , L. A. Goodwin, C. S. Han, T. Woyke, K. W. Davenport, and P. M. Orwin (2013). Genome of the root-associated plant growth-promoting bacterium Variovorax paradoxus strain EPS. Genome Announc. 1(5):e00843-13.

Matson, E. G., A. Z. Rosenthal, X. Zhang, and J. R. Leadbetter (2013). Genome-wide effects of selenium and translational uncoupling on transcription in the termite gut symbiont Treponema primitiamBio 4(6):e00869-13.

Rosenthal, A. Z., X. Zhang, K. S. Lucey, E. A. Ottesen, V. Trivedi, H. M. T. Choi, N. A. Pierce, and J. R. Leadbetter (2013). Localizing transcripts to single cells suggests an important role of uncultured deltaproteobacteria in the termite gut hydrogen economy. Proc. Natl. Acad. Sci. USA 110:16163-8.

Zhang, X. and J. R. Leadbetter (2012). Evidence for cascades of perturbation and adaption in the metabolic genes of higher termite gut symbionts. mBio 3(4):e00223-12.

Ballor, N. R. and J. R. Leadbetter (2012). Patterns of [FeFe] hydrogenase diversity in the gut microbial communities of lignocellulose-feeding higher termites. Appl. Environ. Microbiol. 78:5368-5374.

Ballor, N. R. and J. R. Leadbetter (2012). Analysis of extensive [FeFe] hydrogenase gene diversity within the gut microbiota of insects representing five families of Dictyoptera. Microb. Ecol. 63:586-595.

Ballor, N. R., I. Paulsen, and J. R. Leadbetter (2012). Genomic analysis reveals multiple [FeFe] hydrogenases and hydrogen sensors encoded by treponemes from the H2-rich termite gut. Microb. Ecol. 63:282-294.

Tocheva E. I., E. G. Matson, D. M. Morris , F. Moussavi, J. R. Leadbetter, and G. J. Jensen (2011). Peptidoglycan remodeling and conversion of an inner membrane into an outer membrane during sporulation. Cell 146:799-812.

Tadmor, A. D., E. A. Ottesen, J. R. Leadbetter, and R. Phillips (2011). Probing individual environmental bacteria for viruses by using microfluidic digital PCR. Science 333:58-62 (Cover).

[Link to Commentary]

Chen, S., M. Beeby, G. E. Murphy, J. R. Leadbetter, D. R. Hendrixson, A. Briegel, Z. Li, J. Shi, E. I. Tocheva, A. Muller, M. J. Dobro, and G. J. Jensen (2011). Structural diversity of bacterial flagellar motors. EMBO J. 30:2972-2981.

Matson, E. G., K. G. Gora, and J. R. Leadbetter (2011). Anaerobic carbon monoxide dehydrogenase diversity in the homoacetogenic hindgut microbial communities of lower termites and the wood roach. PLoS One 6:e19316.

Ottesen, E. A., and J. R. Leadbetter (2011). Formyltetrahydrofolate synthetase gene diversity in the guts of higher termites with different diets and lifestyles. Appl. Environ. Microbiol. 77:3461-7.

Rosenthal, A. Z., E. G. Matson, A. Eldar, and J. R. Leadbetter (2011). RNA-seq reveals cooperative metabolic interactions between two termite-gut spirochete species in co-culture. ISME J. 5:1133-42.

Zhang, X., E. G. Matson, and J. R. Leadbetter (2011).  Genes for selenium dependent and independent formate dehydrogenase in the gut microbial communities of three lower, wood-feeding termites and a wood-feeding roach. Environ. Microbiol. 13:307-23.

Han, J.-I., H. K. Choi, S. W. Lee, P. M. Orwin, J. Kim, S. L. Laroe, T. G. Kim, J. O'Neil, J. R. Leadbetter, S. Y. Lee, C. G. Hur, J. C. Spain, G. Ovchinnikova, L. Goodwin, and C. Han (2011). Complete genome sequence of the metabolically versatile plant growth-promoting endophyte Variovorax paradoxus S110. J. Bacteriol. 193:1183-90.

Matson, E.G., X. Zhang, and J. R. Leadbetter (2010) Selenium controls transcription of paralogous formate dehydrogenase genes in the termite gut acetogen, Treponema primitia. Environ Microbiol. 12:2245-2258.

Ottesen, E. A. and J. R. Leadbetter (2010) Diversity of formyltetrahydrofolate synthetases in the guts of the wood-feeding cockroach Cryptocercus punctulatus and the omnivorous cockroach Periplaneta americana. Appl. Environ. Microbiol. 76:4909-13.

Murphy, G. E., E. G. Matson, J. R. Leadbetter, H. C. Berg, and G. J. Jensen (2008). Novel ultrastructures of Treponema primitia and their implications for motility. Mol. Microbiol. 67:1184-95.

Warnecke, F., P. Luginbuhl, N. Ivanova, M. Ghassemian, T. H. Richardson, J. T. Stege, M. Cayouette, A. C. McHardy, G. Djordjevic, N. Aboushadi, R. Sorek, S. G. Tringe, M. Podar, H. G. Martin, V. Kunin, D. Dalevi, J. Madejska, E. Kirton, D. Platt, E. Szeto, A. Salamov, K. Barry, N. Mikhailova, N. C. Kyrpides, E. G. Matson, E. A. Ottesen, X. Zhang, M. Hernandez, C. Murillo, L. G. Acosta, I. Rigoutsos, G. Tamayo, B. D. Green, C. Chang, E. M. Rubin, E. J. Mathur, D. E. Robertson, P. Hugenholtz, and J. R. Leadbetter (2007). Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite. Nature 450:560-5.

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Hawkins, A. C., F. H. Arnold, R. Stuermer, B. Hauer, and J. R. Leadbetter (2007). Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone. Appl. Environ. Microbiol. 73: 5775-81

Wang, Y. J., J. J. Huang, and J. R. Leadbetter (2007). Acyl-HSL signal decay: intrinsic to bacterial cell-cell communications. Adv. Appl. Microbiol. 61:27-58.

Ottesen, E. A., J. W. Hong, S. R. Quake, and J. R. Leadbetter (2006). Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science 314:1464-7.

Murphy, G. E., J. R. Leadbetter, and G. J. Jensen (2006). In situ structure of the complete Treponema primitia flagellar motor. Nature 442:1062-4.

Collins, C. H., J. R. Leadbetter, and F. H. Arnold (2006). Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nat. Biotechnol. 24:708-12.

Yang, W. W., J.-I. Han, and J. R. Leadbetter (2006). Utilization of homoserine lactone as a sole source of carbon and energy by soil Arthrobacter and Burkholderia species. Arch. Microbiol. 185:47-54.

Flagan, S. F., and J. R. Leadbetter (2006). Utilization of capsaicin and vanillylamine as growth substrates by Capsicum (hot pepper)-associated bacteria. Environ. Microbiol. 8:560-5.

Huang, J. J., A. Petersen, A., M. Whiteley, and J. R. Leadbetter (2006). Identification of QuiP, the product of gene PA1032, as the second acyl-homoserine lactone acylase of Pseudomonas aeruginosa PAO1. Appl. Environ. Microbiol. 72:1190-1197.

Salmassi, T. M., J. J. Walker, D. K. Newman, J. R. Leadbetter, N. R. Pace, and J. G. Hering (2006). Community and cultivation analysis of arsenite oxidizing biofilms at Hot Creek. Environ. Microbiol. 8:50-59.

Leadbetter, J. R. (2005). Volume Editor - Environmental Microbiology, Vol. 397. In "Methods in ENZYMOLOGY" (J. N. Abelson and M. I. Simon, Editors). Elsevier - Academic Press.

[Weblink to TOC and Abtracts].

Wang, Y.-J., and J. R. Leadbetter (2005). Rapid acyl-homoserine lactone quorum signal decomposition by diverse soils. Appl. Environ. Microbiol. 71:1291-1299 (Cover).

Collins, C. H., F. H. Arnold, and J. R. Leadbetter (2005). Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Mol. Microbiol. 55:712-723.

Vu, A. T., N. C. Nguyen, and J. R. Leadbetter (2004). Iron reduction in the metal-rich guts of wood-feeding termites. Geobiology 2:239-247.

Graber, J. R., J. R. Leadbetter, and J.A. Breznak (2004). Description of Treponema azotonutricium sp. nov. and Treponema primitia sp. nov., the first spirochetes isolated from termite guts. Appl. Environ. Microbiol. 70:1315-1320.

Huang, J. J., J.-I. Han, L.-H. Zhang, and J. R. Leadbetter (2003). Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1. Appl. Environ. Microbiol. 69:5941-5949.

Salmassi, T. M. & J. R. Leadbetter (2003). Analysis of genes of tetrahydrofolate-dependent metabolism from cultivated spirochaetes and the gut community of the termite Zootermopsis angusticollis. Microbiology-UK 149:2529-2537. (Cover).

Leadbetter, J. R. (2003). Cultivation of recalcitrant microbes: cells are alive, well, and revealing their secrets in the 21st century laboratory. Curr. Opin. Microbiol. 6:274-281.

Yokobayashi, Y., C. H. Collins, J. R. Leadbetter, R. Weiss, and F. H. Arnold (2003). Evolutionary design strategies for synthetic genetic circuits. Adv. Complex Syst. 6:1-9.

Flagan, S., W.-K. Ching, and J. R. Leadbetter (2003). Arthrobacter strain VAI-A utilizes acyl-homoserine lactone inactivation products and stimulates quorum signal biodegradation by Variovorax paradoxus. Appl. Environ. Microbiol. 69:909-916.

Lin, Y.-H., J.-L. Xu, J. Hu, L.-H. Wang, S. L. Ong, J. R. Leadbetter, and L.-H. Zhang (2003). Acyl-homoserine lactone acylase from Ralstonia str. XJ12B represents a novel and potent class of quorum quenching enzymes. Mol. Microbiol. 47:849-860.

Breznak, J. A. and J. R. Leadbetter (2002). Termite gut spirochetes. In: The Prokaryotes - an evolving electronic resource for the microbiological community. M. Dworkin, S. Falkow, E. Rosenberg, K.H. Schleifer, E. Stackebrandt (editors). Springer-Verlag, New York.

Lilburn, T. G., K. S. Kim, N. E. Ostrom, K. R. Byzek, J. R. Leadbetter, and J. A. Breznak (2001). Nitrogen fixation by symbiotic and free-living spirochetes. Science 292:2495-2498.

Leadbetter, J. R. (2001). Plant microbiology - quieting the raucous crowd. Nature 411:748-749.

Leadbetter, J. R. and E. P. Greenberg (2000). Metabolism of acyl-homoserine lactone quorum sensing signals by Variovorax paradoxus. J. Bacteriol. 182:6921-6926.

Leadbetter, J. R., T. M. Schmidt, J. R. Graber, and J. A. Breznak (1999). Acetogenesis from H2 plus CO2 by spirochetes from termite guts. Science 283:686-689.

Lie, T. J., J. R. Leadbetter, and E. R. Leadbetter (1998). Metabolism of sulfonic acids and other organosulfur compounds by sulfate-reducing bacteria. Geomicrobiol. J. 15:135-149.

Leadbetter, J. R., L. D. Crosby, and J. A. Breznak (1998). Methanobrevibacter filiformis sp. nov., a filamentous methanogen from termite hindguts. Arch. Microbiol. 169:287-292.

Lie, T. J., T. Pitta, W. Godchaux, E. R. Leadbetter, and J. R. Leadbetter (1996). Sulfonates: novel participants in anaerobic respiration. Arch. Microbiol. 166:204-209.

Leadbetter, J. R. and J. A. Breznak (1996). Physiological ecology of Methanobrevibacter cuticularis sp. nov. and Methanobrevibacter curvatus sp. nov., isolated from the hindgut of the termite Reticulitermes flavipes. Appl. Environ. Microbiol. 62:3620-3631.

Smith, J. J., J. S. Scott-Craig, J. R. Leadbetter, G. L. Bush, D. L. Roberts & D. W. Fulbright (1994). Characterization of random amplified polymorphic DNA (RAPD) products from Xanthomonas campestris and some comments on the use of RAPD products in phylogenetic analysis. Mol. Phylogenet. Evol. 3:135-145.

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